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Guide for North American Pharmacist Licensure Examination

Quiz North American Pharmacist Licensure Examination

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/ 10

Quiz

1/10
Which of the following represents the major route of metabolism for acetaminophen?
Select the answer
1 correct answer
A.
Glucuronidation
B.
Sulfation
C.
Cytochrome P-450 oxidation
D.
Direct renal excretion
E.
Plasma breakdown

Quiz

2/10
A 15-year-old presents with 6 days of nasal congestion with thin, clear rhinorrhe a. She notes mild facial pain but has had no fevers. She feels her symptoms are improving. What is the most likely cause of her symptoms?
Select the answer
1 correct answer
A.
Streptococcus pneumoniae
B.
Viral
C.
Moraxella catarrhalis
D.
Haemophilus influenzae
E.
Staphylococcus aureus

Quiz

3/10
A 72-year-old woman suffers from a major depressive episode. She has a history of coronary artery disease, atrial fibrillation on anticoagulation therapy, sick sinus syndrome, glaucoma, and chronic obstructive pulmonary disease. Which of the following medications is most appropriate for the treatment of her depression?
Select the answer
1 correct answer
A.
Amitriptyline
B.
Nortriptyline
C.
Doxepin
D.
Fluvoxamine
E.
Escitalopram

Quiz

4/10
A 20-year-old student came to the emergency department with primary complaints of palpitations, low-grade fever, and anxiety for 2 months. She reports that she is irritable and suffers severe mood swings that is interfering with her sleep and relationships (she admits to crying spells and frequent fights with friends and family). She has also lost 12 pounds in the past 2 months with no apparent alteration in her diet or physical activity (though she is happy with her weight loss). She denies any past medical problems, though her friends have always been worried that she eats too little. Her temperature is 38.0 C (100.4 F), blood pressure is 148/62 mm Hg, pulse is 122/min and regular, and respiratory rate is 28/min. Examination reveals a bruit heard over the anterior neck, fine tremor of the hands, and warm, moist skin. Her eyes and eyelids do not move together during finger following test (with steady head). Laboratory work is sent, including a thyroid panel, but will not be available until tomorrow morning. Which of the following is the most appropriate initial management at this time?
Select the answer
1 correct answer
A.
Diltiazem therapy
B.
Iodine therapy
C.
Methimazole therapy
D.
Propranolol therapy
E.
Referral to a surgeon

Quiz

5/10
What is the best anti-thyroid regimen in a pregnant woman who has clinically significant hyperthyroidism?
Select the answer
1 correct answer
A.
Stop treatment and resume post-partum
B.
Propylthiouracil
C.
Methimazole
D.
Propylthiouracil first trimester followed by methimazole for the remainder of pregnancy
E.
Methimazole first trimester followed by propylthiouracil for the remainder of pregnancy

Quiz

6/10
Which of the following is true regarding extent of absorption of drugs?
Select the answer
1 correct answer
A.
After oral ingestion of drugs, the absorption of drug may be incomplete
B.
Drugs which are too lipophilic cannot cross the lipid cell membrane
C.
Drugs which are too hydrophilic are not soluble enough to cross the water layer adjacent to the cell
D.
P-glycoprotein is an efflux transporter which is present in the enterocytes and it enhances the absorption of drug
E.
Grape juice activates P-glycoprotein leading to substantial inhibition of absorption of drugs

Quiz

7/10
Your patient is a 58-year-old male who presents with onset of severe substernal chest pain and shortness of breath. An ECG reveals an acute STEMI, and he is on his way to the cardiac catheterization suite for percutaneous coronary intervention. Which of the following drugs used in acute coronary syndromes treated with PCI must undergo oxidation by hepatic P450 enzymes to an active form?
Select the answer
1 correct answer
A.
Clopidogrel
B.
Ticlopidine
C.
Eptifibatide
D.
Aspirin
E.
Warfarin

Quiz

8/10
A patient with multibacillary leprosy is on dapsone, clofazimine, and rifampin. Which of the following is true regarding the mechanism of action of the medications listed?
Select the answer
1 correct answer
A.
Dapsone is bacteriostatic because of its inhibitory effects on dihydrofolate reductase
B.
Dapsone is bacteriostatic because of its inhibitory effects on myeloperoxidase
C.
Clofazimine is bactericidal by directly inhibiting bacterial DNA polymerase
D.
Rifampin is bacteriostatic by inhibiting RNA synthesis by blocking DNA-dependent RNA polymerase
E.
Rifampin is bactericidal by inhibiting RNA synthesis by blocking DNA-dependent RNA polymerase

Quiz

9/10
You prescribe doxepin to a 37-year-old woman to treat neurotic excoriations on her arms. The patient is concerned about the side effects of this drug. Which of the following is not a side effect of doxepin:
Select the answer
1 correct answer
A.
Xerostomia
B.
Liver toxicity
C.
Somnolence
D.
Urinary retention
E.
Constipation

Quiz

10/10
Which of the following illnesses is an example of a type III hypersensitivity reaction?
Select the answer
1 correct answer
A.
Lupus
B.
Graves disease
C.
Hashiomoto’s thyroiditis
D.
Allergic rhinitis
E.
Myasthenia gravis
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  • Quiz name:North American Pharmacist Licensure Examination
  • Total number of questions:154
  • Number of questions for the test:50
  • Pass score:80%

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